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A New Kind of TNT and its Good for You?

A New Kind of TNT and its Good for You?

Imagine you have a badly injured leg and its healing really slowly because the injury has caused it to lack blood flow. I am your doctor and I say,

 

“SUP Dude, hows it hanging, (ritualistic fist bump), so let me zap you with this thingy-mabob and I am going to reprogram your skin cells to be new vascular cells. These bitches will go heal up that injured leg? Oh by the way, its called TNT and it has a 98% success rate. You in?”

 

YIKES What in Sam Hill?

 

Well I’d follow with a, results of a known patient (cough*cough*, Pig and mouse), with a surprisingly similar injury, had active blood vessels in the injury site after the treatment and the leg was saved by the second week. Freaking AWESOME! 

 

LETS GET DOWN TO BUSINESS

 Photo by LeonidSad/iStock / Getty Images

Photo by LeonidSad/iStock / Getty Images

Researchers from The Ohio State University Wexner Medical Center designed a nanotechnology-based chip to deliver biological "cargo" for cell conversion. This new technology is referred to as, Tissue Nanotransfection or the very flattering acronym, (TNT).

 

 WTF Does this mean right??? 

 

It means I can turn a skin cell on your arm into a fat cell on your ass, No hahaha well Maybe?!? Ill have to get back to you on that! But it does mean you can basically change a skin cell to say repair injured tissue or restore function of aging tissue. This includes organs, blood vessels and nerve cells. FUCK YES, I don’’t have to look old, thank god. GUYZ Ive been really worrying about that lately.

 

This technology has been shown to reprogram skin cells in the live body into nerve cells. These nerve cells were then injected into brain-injured mice allowing them to successfully recover from stroke. 

 

SOOO, is it invasive & What do you Mean you're Going to “Chip” Me?

 

This new technology can convert your skin cells into the desired cell with one touch. I’ll say it again, ONE TOUCH!!! The process itself takes less than a minute, no, less than a second! It is a completely non-invasive process and the chip does not have to remain in your body for the benefits of reprogramming to start. Because this process all happens within the body, It is under constant immune surveillance and therefore the act of using immune suppression is obsolete.

 Photo by wildpixel/iStock / Getty Images

Photo by wildpixel/iStock / Getty Images

***Immune suppression is used when transplants occur. Doctors will give the patient something to put the immune system at bay that way you don’t get an autoimmune like effect, where your body is attacking itself causing harm. 

 

IN SUMMARY

 

  1. There is a nanotechnology-based chip is designed to deliver cargo to adult cells in the live body.
  2. It is designed for specific biological cargo conversion.
  3. After delivery, this cargo using the chip will convert adult cells from one type to another
  4. TNT is non-invasive and does not require any procedure that is laboratory based. This makes it available to implement at the point of care. 
  5. “Cargo” delivered by a very small zap via electrical charge and is barely felt by the patient. 

 

Clinical trials start next year to test this technology in humans!

 

This research was performed by, Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center.

 

Results of the regenerative medicine study published today in the journal Nature Nanotechnology.

 

My Thoughts

 

First, I did a massive amount of research to try and figure out the actual mechanism behind this because all we are told is its a chip that delivers a small zap and magic happens (basically). I am assuming we will have to wait for the full publication and I cannot wait! Its out but I can’t afford it :D 

 

There are many reasons this is so amazing, one being that we have never been able to change the function of an adult cell, we have only been able to manipulate and derive different forms of cells withpluripotent or hematopoietic stem cells which are basically blank slates of cells, but not with an adult cell. RAD!

 

What are the implications of changing one cell into another? Will this start an unforeseen cascading process? Will this injure the person down the road? Who knows, but be excited, this is rad. I can’t wait to see the human trials.

 

WHAT DO YOU THINK! Did I get anything wrong? What did I miss? Comment below :)

 Photo by SIphotography/iStock / Getty Images

Photo by SIphotography/iStock / Getty Images

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